Ketamine is a drug that has traditionally been used in surgery as an anesthetic. It has, however, been discovered to have a rapid and substantial antidepressant effect in some persons suffering from treatment-resistant depression (TRD). Ketamine can be administered intravenously (IV), intramuscularly (IM), or through nasal spray (esketamine).

The precise mechanism by which ketamine acts for depression is unknown. It is hypothesized, however, to promote the formation of new neuronal connections in the brain, particularly in areas involved in mood regulation. This is in contrast to how traditional antidepressants function, which often take several weeks to kick effect and largely alter the levels of particular neurotransmitters in the brain.

TRD refers to depression that has not responded to several standard antidepressant drugs or therapy. Ketamine has showed potential in the treatment of TRD.

Dissociation,  sedation, elevated blood pressure, dizziness, headache, blurred vision, anxiety, nausea, and vomiting are the most prevalent side effects of ketamine treatment for depression. These adverse effects are often minor and brief, and they can be controlled with appropriate medical supervision.

When taken under competent medical care, ketamine is usually regarded as safe. However, it should be avoided or used with extreme caution in people who have uncontrolled high blood pressure, severe liver or kidney illness, or certain psychiatric problems.

Ketamine for depression treatment can be given intravenously (IV), intramuscularly (IM), or through nasal spray (esketamine). The precise dosing and frequency of treatment will differ according to the individual’s needs and response to the medicine. Ketamine treatment should never be given without the supervision of a trained medical practitioner.

In conclusion, ketamine treatment for depression is a promising new approach for people suffering from treatment-resistant depression.